Figure 1.

Screening of a selected number of FDA-approved drugs in the radiosensitisation of HNSCC cells. (A) Schematic of the drug-radiation screen utilising FaDu cells grown as 3D spheroids and then analysing growth over a period of 3–15 days post-seeding. Analysis of FaDu spheroid growth between 3 and 15 days post-seeding after a single 1 Gy dose of X-rays in the presence of 183 drugs at either (B) 0.03 µM or (C) 1 µM dose. Growth was analysed from a single replicate and normalised against the DMSO-treated control (first lane, yellow bar), which was set to 1.0. Indicated in green arrows are the HDAC inhibitors identified as potential radiosensitisers.