Figure 1.

Characteristics of TP53 mutations in patients within the TP53-mutated group. More than half of the identified TP53 mutations were missense mutations, with the majority occurring in the DNA-binding domain (DBD). Each circle represents a codon where a TP53 mutation occurred, with mutation type distinguishing by color. The number of circles indicate the total number of mutations occurring within specific codons. (Abbreviation, TAD; transactivation domain, PRD; proline-rich domain, OD; oligomerization domain, CTD; carboxy-terminal domain).