Table 2.

Top 30 genes with highest association level predicted by STRING and cytoHubba. miRNAs shown in red and blue are those up-regulated and down-regulated, respectively. Predicted effects are described for top 10 genes. Arrow notations indicate up- or no-regulation (→up/no) and down-regulation (→down) of target genes.

Rank	Gene	miRNA	Predicted Effects	Rank	Gene	miRNA	Rank	Gene	miRNA
1	Actb	miR-145a-5p	cell motility and contraction→up/no	11	Csf1r	miR-22-3p	21	Mecp2	miR-22-3p
2	Ins1	miR-466f-3p	blood glucose decrease→down	12	Sirt1	miR-22-3p	22	Mlxipl	miR-706
3	Fgf17	miR-423-5p	normal brain development→down	13	H3f3b	miR-22-3p	23	Socs1	miR-19b-3p
4	Fgf16	miR-466f-3p	normal heart development→down	14	Angpt2	miR-145a-5p	24	Hnrnph2	miR-145a-5p
5	Grb2	miR-466f-3p	linking of cell growth factor receptor and Ras signaling→down→growth inhibition	15	Cdkn1b	miR-706	25	Pkm	miR-122-5p
6	Ngf	miR-423-5p	normal nerve growth→down	16	Ppara	miR-22-3p	26	Prkcd	miR-466f-3p
7	Erbb3	miR-22-3p	development of various organs and myeloid cell differentiation→up/no	17	Slc2a4	miR-466f-3p	27	Arrb1	miR-22-3p
8	Fgfr2	miR-423-3p	cell proliferation, differentiation, migration, apoptosis→up/no	18	Mycn	miR-19b-3p	28	Sgk1	miR-19b-3p
9	Kitl	miR-466f-3p	cell survival, proliferation, stem cell maintenance→down	19	Ccnd2	miR-19b-3p	29	Hnrnpf	miR-706
10	Esr1	miR-22-3p	cellular proliferation and differentiation→up/no	20	G6pc3	miR-122-5p	30	Actg1	miR-145a-5p