Table 5.

Genes relevant to the functions of macrophages and phagocytosis. miRNAs shown in red and blue are those that are up-regulated and down-regulated, respectively. Arrow notations indicate the up/no-regulation (→up/no) and down-regulation (→down) of target genes.

Keyword	Gene	miRNA	Predicted Effects
Macrophage	Maf1	miR-122-5p	Required for monocytic, macrophage, osteoclast, and islet beta cell differentiation.→down
	Pkm	miR-122-5p	Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein PD-L1 in ARNTL/BMAL1-deficient macrophages, consequently suppresses immune activity.→down
	Ocln	miR-122-5p	Regulation of the tight junction and macrophage adhesion and spreading →down
	Ifi204	miR-466f-3p	Inhibits cell growth and may be involved in macrophage differentiation.→down
	Il31	miR-22-3p	May function in skin immunity, enhances myeloid progenitor cell survival in vitro, and induces amyloid A protein expression in macrophages.→up/no
	Csf1r	miR-22-3p	Regulation of survival, proliferation and differentiation of macrophages and monocytes and plays an important role in innate immunity and in inflammatory processes.→up/no
	Pdgfd	miR-145a-5p	Plays an important role in wound healing and Induces macrophage recruitment.→up/no
Phagocytosis	Il15ra	miR-466f-3p	Required for IL15-induced phagocytosis in neutrophils→down
	Gulp1	miR-19b-3p	Required for efficient phagocytosis of apoptotic cells.→up/no

Genes in bold are high priority for further analysis in the next research phase.