Table 3.

An overview of pros and cons of AAV vectors and lentiviral vectors.

AAV Vectors	Lentiviral Vectors
Serotypes that can specifically target hepatocytes efficiently	No specific hepatocyte targeting
Typically nonintegrating (episomal)	Integrating into the genome
Potential liver toxicity at high doses	High transduction efficiency of liver is difficult
Stable viral particles	Typically unstable due to viral envelope
Packaging capacity up to 4.7 Kb	Packaging capacity up to 8 Kb
Prevalent pre-existing immunity in adult population