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. 2024 Nov 25;25(23):12635. doi: 10.3390/ijms252312635

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dopaminergic phenotype (DP) in the Substantia nigra pars compacta (SNpc). (a) Principal component analysis that plots the DP in the SNpc of Ctrl, Nano-PSO/ROT, ROT/Nano-PSO, and ROT rats. The graph shows the magnitude of SNpc DP variability and the probability of their variance (ellipses). (b) Complete linkage clustering dendrogram that shows the degree of similitude of SNpc DPs within and between Ctrl, Nano-PSO/ROT, ROT/Nano-PSO, and ROT rats. The greatest phenotypic similarity is found when the phenotypes are adjacent, are close to the branching points, and appear along with less complex branching patterns. Abbreviations: dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), DA:DOPAC ratio (DA:DOPA), and serotonin (5HT).