Figure 2.

This image illustrates the impact of H. pylori infection on the aging stomach and its potential role in “Anorexia of Aging”. The image shows how H. pylori can penetrate the mucus layer of the stomach, causing disruption of the epithelial barrier and apoptosis (programmed cell death), which contributes to elevated reactive oxygen species (ROS) levels. The damage is further aggravated by atrophic gastric glands and reduced blood supply, which are associated with aging. These conditions lead to a weakened gastric environment. This weakening contributes to hypochlorhydria (reduced stomach acid), causing iron malabsorption, bacterial overgrowth, and vitamin B12 deficiency. This impaired environment can manifest in symptoms like delayed gastric emptying, gastro-esophageal reflux, and dyspepsia, collectively contributing to Anorexia of Aging. Additionally, the impact of external factors such as stress and NSAIDs is highlighted, indicating their role in exacerbating stomach issues in aging individuals. Create with biorender.