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The key step of puromycin biosynthesis is mediated by the unique enzyme Pur6. (A) A schematic representation of the reaction catalyzed by Pur6 that was proposed in [11]. (B) Pur6 structure model generated by AlfaFold3 (grey) aligned with cysteine proteinase (green) gingipain R (PDB ID: 1CVR). Essential catalytic Cys244 residue of gingipain R and Cys326 residue of Pur6 are indicated as yellow spheres.
