Fig. 4. Immunometabolic relationships define clinical subgroups in DS.
(A) Hierarchically clustered differences in mean feature abundance (IMS versus all others) separated by immunometabolic subgroups. Co-occurring conditions were tested for enrichment across subgroups (signed −log10 q values of one-sided Fisher’s exact tests; *FDR < 0.2). (B) Log odds ratios for reported co-occurring conditions in relation to each immunometabolic subgroup. (C) Alluvial plot demonstrating the distribution of individuals across subgroups based on cytokine profiles, metabolite profiles, or immunometabolic profiles. (D to H) Standardized abundances of individual cytokines or metabolites across immunometabolic subgroups and in relationship to individuals with D21 karyotype. TCA, tricarboxylic acid.