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. 2024 Dec 2;25(23):12962. doi: 10.3390/ijms252312962

Figure 8.

Figure 8

Effect of HCA preconditioning on cardiac I/R-induced 4HNE/GPX4-mediated ferroptosis and caspase 3-mediated apoptosis in the three groups. Typical GPX4 and 4HNE stains of the three groups are displayed in (A,B), respectively. The percentages of staining of 4HNE and GPX4 sections in the three groups are indicated in (C,D). Cardiac TUNEL expression in the three groups is shown in (E). Statistical analysis of caspase 3 activity is presented in (F). Statistical analysis of TUNEL-positive cells in the three groups is presented in (G). All data are expressed as mean ± SEM (n = 3). * indicates significant differences vs. sham group (** p < 0.01; *** p < 0.001; **** p < 0.0001). # indicates significant differences vs. I/R group (### p < 0.001; #### p < 0.0001).