Figure 1.

Effect of BCG and M. brumae on wound healing of BC cells. BCG infection significantly reduces cell migration in both the 5637 and SW780 BC cell lines, while M. brumae infection significantly decreases migration in the 5637 cell line. One representative experiment is shown for T24 (A), 5637 (B), and SW780 (C) cell lines at T = 0 and T = 2. The scale of the images is comparable. Graphs show percentage of occupied area by non-infected (control) and mycobacteria-infected cells at different time points (T = 0, 0 h; T = 1, 16 h; T = 2, 24 h) for T24 (D), 5637 (E), and SW780 (F) cell lines. Data represent the means ± SD from three independent experiments. Statistical comparisons were performed using Student’s t-test. **** p < 0.0001; ** p < 0.01; * p < 0.05 versus non-infected cells.