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. 2024 Dec 6;25(23):13115. doi: 10.3390/ijms252313115

Figure 2.

Figure 2

Discriminative protein signatures between RAS-mut and RAS-wt NIFTPs identified by MALDI-MSI. (A) Peptide spectra derived from the analysis of the annotated NIFTP regions. (B) PCA score plot of the individual spectra. (C) Comparative heatmap and hierarchical clustering of the expression levels of the 24 m/z signals with the highest discriminatory potential (AUC ≥ 0.75) for RAS-mut vs. RAS-wt NIFTPs. AUC, area under the curve; MALDI-MSI, MALDI-MSI, matrix-assisted laser desorption/ionization mass spectrometry imaging; mut, mutant; NIFTP, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; PCA, principal component analysis; wt, wild-type.