Figure 1.

Amyloid accumulation in Alzheimer’s disease. This figure illustrates the process of amyloid-beta (Aβ) peptide formation and accumulation, a hallmark of Alzheimer’s disease pathology. Targeting Aβ oligomers is significant because these smaller aggregates are more neurotoxic than amyloid plaques. Aβ oligomers disrupt synaptic function, impair ion homeostasis, and activate detrimental signaling pathways, making them a critical focus for therapeutic interventions aimed at halting disease progression.