Table 4.
Patients presenting the ACTA2 gene and their characteristics.
| No. | First Author/Year/Reference | No. of Patients/Gender/Age | Medical History of Aortic Disease | Family History of Aortic Disease | Clinical Features | Healthy Pregnancy |
|---|---|---|---|---|---|---|
| 1. | Hoffjan et al., 2011 [32] | 3 patients a. F, 38 b. F, 37 c. M, 41 |
a. Mild aortic dilation b. Acute aortic dissection c. Thoracic aortic aneurysm |
a. 1 brother had ascending aorta aneurysm and died at 46 years old; 1 brother and the father had thoracic aortic aneurysm b. 1 brother died at 29 years old from acute aortic dissection c. no data available |
Not described | a. 2 healthy pregnancies b. 2 healthy pregnancies c. - |
| 2. | Keravnou et al., 2018 [36] | 1/M/30 | Type A aortic dissection | Father had aortic root and ascending aorta aneurysm (Bentall procedure performed) Mother had ascending aortic dilation |
Not described | - |
| 3. | Marutani et al., 2023 [37] | 1/M/15 | Extensive dissection from the ascending aorta to the common iliac artery | Genetic tests not performed | Not described | - |
| 4. | Ware et al., 2014 [33] | 1/M/17 | Recurrent aortic dissection, severe aortic regurgitation | Twin brother had aortic dissection | Congenital mydriasis (both twins) | - |
| 5. | Delsart et al., 2021 [38] | 1/F/29 | DeBakey type I aortic dissection | 2 siblings had acute aortic dissection Mother died at 49 years old from type B aortic dissection |
Not described | No pregnancies |