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Mosaic variants change VAF between batches of DNA. HG002 mosaic benchmark variant allele fractions (VAFs) for NIST reference material (RM) 8391 and different batches of non-RM DNA (Coriell, NA24385) for two orthogonal technologies (Element and PacBio Revio). Higher VAFs were observed in direct VAF comparisons between materials compared to GIAB reference material. Coverage: Element RM: 136x, non-RM: 100x; PacBio Revio RM: 48x, non-RM: 120x.
