Table 1:
Posterior mean estimates of meiotic and mitotic error probabilities inferred with ABC across a range of target proportions of euploid, mosaic, and aneuploid embryo biopsies reported in the literature based on PGT-A. Estimates are shown across three levels of dispersal (0, 0.5, and 1). The posterior distributions of meiotic and mitotic error probabilities were used to simulate embryos, and the proportions of fully aneuploid, mosaic aneuploid, and fully euploid simulated embryos are also reported.
| Data set | Dispersal | Published biopsy data | Inferred probabilities | Inferred embryo types | |||||
|---|---|---|---|---|---|---|---|---|---|
| Euploid | Mosaic | Aneuploid | Meiotic error | Mitotic error | Fully euploid | Mosaic aneuploid | Fully aneuploid | ||
| Capalbo et al. (2021) | 0 | 0.23 | 0.19 | 0.58 | 0.39 | 0.064 | 0.00 | 0.60 | 0.40 |
| Clarke et al. (2023) | 0 | 0.49 | 0.18 | 0.33 | 0.30 | 0.024 | 0.00 | 0.70 | 0.30 |
| Munné et al. (2017) | 0 | 0.53 | 0.15 | 0.32 | 0.31 | 0.017 | 0.00 | 0.69 | 0.31 |
| Rodrigo et al. (2020) | 0 | 0.51 | 0.06 | 0.43 | 0.38 | 0.016 | 0.00 | 0.62 | 0.38 |
| Capalbo et al. | 0.5 | 0.23 | 0.19 | 0.58 | 0.59 | 0.021 | 0.00 | 0.43 | 0.57 |
| Clarke et al. | 0.5 | 0.49 | 0.18 | 0.33 | 0.34 | 0.011 | 0.00 | 0.67 | 0.33 |
| Munné et al. | 0.5 | 0.53 | 0.15 | 0.32 | 0.33 | 0.009 | 0.01 | 0.67 | 0.32 |
| Rodrigo et al. | 0.5 | 0.51 | 0.06 | 0.43 | 0.43 | 0.011 | 0.00 | 0.58 | 0.42 |
| Capalbo et al. | 1 | 0.23 | 0.19 | 0.58 | 0.58 | 0.015 | 0.00 | 0.42 | 0.58 |
| Clarke et al. | 1 | 0.49 | 0.18 | 0.33 | 0.32 | 0.008 | 0.01 | 0.66 | 0.33 |
| Munné et al. | 1 | 0.53 | 0.15 | 0.32 | 0.32 | 0.007 | 0.02 | 0.65 | 0.33 |
| Rodrigo et al. | 1 | 0.51 | 0.06 | 0.43 | 0.42 | 0.017 | 0.00 | 0.58 | 0.42 |