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[Preprint]. 2025 Jul 25:2024.11.26.625484. Originally published 2024 Dec 2. [Version 2] doi: 10.1101/2024.11.26.625484

Table 1:

Posterior mean estimates of meiotic and mitotic error probabilities inferred with ABC across a range of target proportions of euploid, mosaic, and aneuploid embryo biopsies reported in the literature based on PGT-A. Estimates are shown across three levels of dispersal (0, 0.5, and 1). The posterior distributions of meiotic and mitotic error probabilities were used to simulate embryos, and the proportions of fully aneuploid, mosaic aneuploid, and fully euploid simulated embryos are also reported.

Data set Dispersal Published biopsy data Inferred probabilities Inferred embryo types
Euploid Mosaic Aneuploid Meiotic error Mitotic error Fully euploid Mosaic aneuploid Fully aneuploid
Capalbo et al. (2021) 0 0.23 0.19 0.58 0.39 0.064 0.00 0.60 0.40
Clarke et al. (2023) 0 0.49 0.18 0.33 0.30 0.024 0.00 0.70 0.30
Munné et al. (2017) 0 0.53 0.15 0.32 0.31 0.017 0.00 0.69 0.31
Rodrigo et al. (2020) 0 0.51 0.06 0.43 0.38 0.016 0.00 0.62 0.38
Capalbo et al. 0.5 0.23 0.19 0.58 0.59 0.021 0.00 0.43 0.57
Clarke et al. 0.5 0.49 0.18 0.33 0.34 0.011 0.00 0.67 0.33
Munné et al. 0.5 0.53 0.15 0.32 0.33 0.009 0.01 0.67 0.32
Rodrigo et al. 0.5 0.51 0.06 0.43 0.43 0.011 0.00 0.58 0.42
Capalbo et al. 1 0.23 0.19 0.58 0.58 0.015 0.00 0.42 0.58
Clarke et al. 1 0.49 0.18 0.33 0.32 0.008 0.01 0.66 0.33
Munné et al. 1 0.53 0.15 0.32 0.32 0.007 0.02 0.65 0.33
Rodrigo et al. 1 0.51 0.06 0.43 0.42 0.017 0.00 0.58 0.42