Table 3.

Sputum processing step that are significantly associated with dsWGS success based on the whole genome coverage generalized linear model.

Characteristic	OR	95% CI	p-value
Smear neg	ref
2+,1+,scanty	3.4	(0.98, 12.1)	0.07
3+	14.7	(3.5, 62.1)	0.0005
Mechanical lysis	193.3	(11.7, 3197.8)	0.008
Enzymatic/Chemical lysis	18.5	(1.9, 183.1)	0.02
Decontamination	0.005	(0.001, 0.03)	7e-06
Heat Inactivation	2.25	(1.1, 4.5)	0.02

Associations were performed using a sample-level logistic regression model pooled across studies with dsWGS success defined as whole genome coverage >90% at read depth of >5x per site. OR = Odds Ratio, CI = Confidence Interval.