Fig. 3. Cis-regulatory effects are cell type-specific and disease state-specific.

(A) Number of shared and disease state-specific eGenes within each cell type. (B) Significant condition-specific eGene (lfsrCTL < 0.10 and lfsrCOVID > 0.30, lfsrCOVID < 0.10 and lfsrCTL > 0.30) sharing patterns across cell types in healthy controls and COVID-19 patients. Patient-specific eGene sets are highlighted by color per cell type. (C) Example of a patient-specific genetic effect (i.e., SARS-CoV-2 response eQTL) present only in CD14⁺ monocytes in the gene SCAMP1 (healthy controls, top plots; COVID-19 patients, bottom plots).