Fig. 7. Putative secondary binding site in other SMYD proteins.

(A) Sequence alignment of SMYD2, SMYD1, and SMYD3 at the secondary binding site. SMYD2 residues directly interacting with PARP1 are indicated by asterisks above the alignment. Completely identical residues are shown as white on black, and similar residues appear shaded in cyan. (B) A putative binding site in SMYD1 and SMYD3 at a location structurally equivalent to the secondary binding site in SMYD2. (C) Sequence alignment of SMYD proteins at the secondary binding site across species.