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. 2024 Dec 13;20(12):e1011496. doi: 10.1371/journal.pgen.1011496

Fig 2. PAT-3/UNC-112/TLN-1 adhesome axis and other adhesome components present in RPM-1 proteomics are linked to human neurobehavioral deficits.

Fig 2

A) Illustration of PAT-3/UNC-112/TLN-1 adhesome axis that includes two integrin receptors PAT-3 (β-Integrin, green) and PAT-2 (α-Integrin, green), the UNC-112 Kindlin complex (light green), and the TLN-1 Talin complex (dark green). B) Summary of RPM-1 AP-proteomics data from C. elegans integrated with a computationally predicted protein-protein interaction network (lines) and genetic links to human neurobehavioral abnormalities (orange halo). Adhesome components enriched in RPM-1 AP-proteomics are highlighted in color with increasing circle size denoting significance (GS::RPM-1 test samples versus GS::GFP negative controls). Highlighted (shades of green) are Integrins, UNC-112 Kindlin complex and TLN-1 Talin complex. Also shown are additional adhesome components detected (blue) or absent (gray) in RPM-1 AP-proteomics. Orthologous human protein annotated in brackets. Data is presented from 7 independent RPM-1 AP-proteomics experiments. Significance determined using Mann-Whitney test. ns = not significant.