Fig 3. Vaccination with INI-4001-adjuvanted VLP decreases viral RNA burden in multiple tissues post-challenge.

Mice prime-boost vaccinated 3 weeks apart with PBS, VLP alone, or adjuvanted VLP. n=5/group. Vaccinated mice infected ip with 10⁴ FFU POWV-LB 4 weeks post-boost. Viral load was measured in tissues harvested 6 days post-infection by RT-qPCR. Data are reported as log-transformed mean ± SEM. Statistical significance was determined on log-transformed data using one-way ANOVA with Šídák’s multiple comparisons to mock-vaccinated mice within each compartment.