Figure 3. Pre-exposure to the context prior to fear conditioning partially rescues freezing behavior in ΔCTD GluA1 mice.

A: Schematic of pre-exposure contextual fear conditioning paradigm. B, C: Freezing across time (B) and average freezing (C) during contextual fear conditioning for WT and ΔCTD GluA1 mice. Foot shocks are indicated with vertical red dashed lines. Horizontal dashed line indicates baseline freezing (percentage of time spent freezing during the 5 min. prior to the first shock). D, E: Freezing % across time (D) and average freezing % (E) during context recall test for WT and ΔCTD GluA1 mice. Error bars represent SEM. Empty dots represent females, filled dots represent males. n.s., not statistically different; **, p≤0.01. B, D: two-way ANOVA. C: Mann-Whitney test. E: Welch’s t-test.