Table 1: Clinical characteristics of ethnic minority subjects with AF stratified by presence of rare missense TTN variants.
*Data are missing for the following variables: eGFR (1), electrocardiogram within 3 months of AF diagnosis (11), LVEDD (19), left atrial size (6), left atrial diameter (21). Left ventricular dilatation is defined as left ventricular end diastolic diameter greater than 2 standard deviations above the normal sex-specific mean value. Variants with a REVEL score ≥ 0.7 were defined as predicted deleterious. Continuous data are represented as mean (standard deviation) and categorical data are represented as count (%).
| TTN Missense Absent | TTN Missense Present | Total | ||
|---|---|---|---|---|
| (N=54) | (N=77) | (N=131) | P-value | |
| Mean age at AF diagnosis (years) | 64.3 (15.2) | 62.9 (12.9) | 63.5 (13.8) | 0.575 |
| Male sex | 30 (55.6%) | 40 (51.9%) | 70 (53.4%) | 0.724 |
| Race/ethnicity | 0.696 | |||
| Non-Hispanic Black | 37 (68.5%) | 56 (72.7%) | 93 (71.0%) | |
| Hispanic/Latinx | 17 (31.5%) | 21 (27.3%) | 38 (29.0%) | |
| BMI (kg/m2) | 33.7 (9.0) | 34.2 (10.1) | 34.0 (9.6) | 0.765 |
| Diabetes | 18 (33.3%) | 32 (41.6%) | 50 (38.2%) | 0.366 |
| Hypertension | 45 (83.3%) | 68 (88.3%) | 113 (86.3%) | 0.448 |
| Coronary artery disease | 13 (24.1%) | 20 (26.0%) | 33 (25.2%) | 0.841 |
| History of stroke/transient ischemic attack | 8 (14.8%) | 18 (23.4%) | 26 (19.8%) | 0.270 |
| Congestive heart failure | 21 (38.9%) | 33 (42.9%) | 54 (41.2%) | 0.720 |
| Nonischemic dilated cardiomyopathy | 4 (7.7%) | 8 (11.1%) | 12 (9.7%) | 0.760 |
| Estimated glomerular filtration rate (mg/dL) | 71.8 (24.4) | 67.2 (24.7) | 69.1 (24.6) | 0.297 |
| Ventricular rate | 92.1 (29.0) | 97.5 (29.6) | 95.3 (29.4) | 0.326 |
| QRS interval (ms) | 97.6 (23.7) | 100.2 (28.1) | 99.2 (26.3) | 0.593 |
| QTc interval (ms) | 449.6 (37.7) | 466.5 (42.3) | 459.6 (41.2) | 0.027 |
| Left ventricular ejection fraction (%) | 0.722 | |||
| Normal (≥50%) | 32 (59.3%) | 45 (58.4%) | 77 (58.8%) | |
| Mildly decreased (40–49%) | 7 (13.0%) | 7 (9.1%) | 14 (10.7%) | |
| Moderately decreased (30–39%) | 4 (7.4%) | 9 (11.7%) | 13 (9.9%) | |
| Severely decreased (20–29%) | 7 (13.0%) | 9 (11.7%) | 16 (12.2%) | |
| Very severely decreased (< 20%) | 4 (7.4%) | 7 (9.1%) | 11 (8.4%) | |
| Left ventricular end diastolic diameter (mm) | 45.3 (9.2) | 47.8 (9.8) | 46.7 (9.5) | 0.180 |
| Left ventricular dilatation | 4 (8.3%) | 13 (20.3%) | 17 (15.2%) | 0.111 |
| Left atrial size | 0.675 | |||
| Normal | 17 (32.7%) | 21 (28.8%) | 38 (30.4%) | |
| Mildly dilated | 15 (28.8%) | 23 (31.5%) | 38 (30.4%) | |
| Moderately dilated | 13 (25.0%) | 17 (23.3%) | 30 (24.0%) | |
| Severely dilated | 7 (13.5%) | 12 (16.4%) | 19 (15.2%) | |
| Left atrial diameter (mm) | 39.6 (7.4) | 41.2 (7.7) | 40.5 (7.6) | 0.286 |
| Number of TTN missense variants | - | |||
| 0 | 54 (100.0%) | 0 (0.0%) | 54 (41.2%) | |
| 1 | 0 (0.0%) | 37 (48.1%) | 37 (28.2%) | |
| 2 | 0 (0.0%) | 26 (33.8%) | 26 (19.8%) | |
| >2 | 0 (0.0%) | 14 (18.2%) | 14 (10.7%) | |
| Number of predicted deleterious TTN missense variants | - | |||
| 0 | 54 (100.0%) | 34 (44.2%) | 88 (67.2%) | |
| 1 | 0 (0.0%) | 34 (44.2%) | 34 (26.0%) | |
| 2 | 0 (0.0%) | 9 (11.7%) | 9 (6.9%) |