Figure 4: Lower, but not significant, binding and neutralization antibody levels were observed with the immunocompromised individuals.

Binding and neutralizing antibody levels compared for 70 immunocompetent and 17 immunocompromised study participants. NT50 values were transformed due to skew in the data (log10 of NT50+1 transformation). (a) S1- and S2-specific antibody levels measured by ELISA using S1-Wuhan, S2-Wuhan, S1-Omicron, and S2-Omicron as antigens. (b) Serum antibody neutralizing concentrations (50% neutralization titer; NT50) were determined against Wuhan, Omicron, SARS-CoV and W1V1-CoV pseudoviruses. For each measurement, immunocompetent and immunocompromised means were analyzed using a t-test. Statistical significance was defined as *P < 0.05, **P < 0.01, and *** P < 0.001.