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[Preprint]. 2024 Dec 5:rs.3.rs-5487774. [Version 1] doi: 10.21203/rs.3.rs-5487774/v1

Figure 4: Lower, but not significant, binding and neutralization antibody levels were observed with the immunocompromised individuals.

Figure 4:

Binding and neutralizing antibody levels compared for 70 immunocompetent and 17 immunocompromised study participants. NT50 values were transformed due to skew in the data (log10 of NT50+1 transformation). (a) S1- and S2-specific antibody levels measured by ELISA using S1-Wuhan, S2-Wuhan, S1-Omicron, and S2-Omicron as antigens. (b) Serum antibody neutralizing concentrations (50% neutralization titer; NT50) were determined against Wuhan, Omicron, SARS-CoV and W1V1-CoV pseudoviruses. For each measurement, immunocompetent and immunocompromised means were analyzed using a t-test. Statistical significance was defined as *P < 0.05, **P < 0.01, and *** P < 0.001.