. 2024 Dec 13;13:RP96691. doi: 10.7554/eLife.96691

Appendix 1—table 1. Table of model parameters.

Model parameters
$C_{m}$	23.13 nF (19.5 in OVX + E2)
Current parameters ^*						Reference
$I_{N a T}$	$τ_{h, N a T}$	4.5 ms	$V_{h, N a T}$	–43.2 mV		Fry et al., 2007
	$V_{m, N a T}$	–25 mV	$k_{m, N a T}$	3 mV
	$k_{h, N a T}$	–8.2 mV	$g_{N a T}$	90 nS
	$E_{N a}$	66.1 mV
$I_{N a P}$	$τ_{h, N a P}$	250 ms	$V_{h, N a P}$	–47.4 mV		Zhang et al., 2015; Moran et al., 2016
	$V_{m, N a P}$	–41.5 mV	$k_{m, N a P}$	3 mV
	$k_{h, N a P}$	–8.5 mV	$g_{N a P}$	3.37 nS
	$E_{N a}$	66.1 mV
$I_{A}$	$τ_{h, A}$	10 ms	$V_{h, A}$	–55.1 mV		Mendonça et al., 2016; Mendonça et al., 2018
	$τ_{m, A}$	20 ms	$V_{m, A}$	–30 mV
	$k_{h, A}$	–11.4 mV	$k_{m, A}$	10 mV
	$g_{A}$	60 nS in OVX 35 in OVX + E2	$E_{K}$	–81 mV
$I_{B K}$	$k_{B K}$	10 mV	$k_{s h i f t}$	18 mV		Tsaneva-Atanasova et al., 2007
	$V_{B K, 0}$	–22.52 mV	$k_{c, B K}$	1.5 μM
	$g_{B K}$	13.50 nS in OVX; 20 nS in OVX + E2	$E_{K}$	–81 mV
$I_{S K}$	$K_{S K}$	0.45 μM	$n$	4		Bond et al., 1999
$I_{S K}$	$g_{S K}$	28.13 nS in OVX; 26.05 nS in OVX + E2	$E_{K}$	–81 mV		Bond et al., 1999
$I_{M}$	$τ_{m, M}$	10 ms	$V_{m, M}$	–50 mV		Nowacki et al., 2011; Conde and Roepke, 2020
	$k_{m, M}$	20 mV	$g_{M}$	0.23 nS in OVX 1.23 ns in OVX + E2
	$E_{K}$	–81 mV
$I_{h}$	$τ_{m, h, 1}$	80 ms	$V_{m, h, 1}$	–102 mV		Gottsch et al., 2011; Booth et al., 2016; Qiu et al., 2018
	$τ_{m, h, 1}$	310 ms	$V_{m, h, 2}$	–102 mV
	$p_{h}$	0.85	$k_{m, h, 1}$	–10 mV
	$k_{m, h, 2}$	–10 mV	$g_{h}$	0.56 nS (11.23 nS in OVX + E2)
	$E_{h}$	–27.8 mV
$I_{T}$	$τ_{h, T, 1}$	1.94 ms	$V_{h, T, 1}$	–69.1 mV		Zhang et al., 2015; Wang et al., 2016
	$τ_{h, T, 2}$	86.3 ms	$V_{h, T, 2}$	–69.1 mV
	$p_{h}$	0.5	$V_{m, T}$	–54 mV
	$k_{h, T, 1}$	–5.3 mV	$k_{h, T, 2}$	–5.3 mV
	$k_{m, T}$	3.3 mV	$g_{T}$	0.66 nS (5 nS in OVX + E2)
$I_{C a}$	$τ_{h, C a}$	10 ms	$V_{h, C a}$	–48.9		fitted
	$τ_{m, C a}$	300 ms	$V_{m, C a}$	–27.3 mV
	$k_{h, C a}$	–18.2	$k_{m, C a}$	4.62 mV
	$g_{C a}$	2.1 nS (2.8 nS in OVX + E2)	$E_{C a}$	121.6 mV
$I_{T R P C 5}$	$c_{T R P C 5}$	0.6 μM	$k_{T R P C 5}$	0.33 μM		Qiu et al., 2021
	$k_{R_{T R P C 5}}$	0.006 ms^–1	$k_{- R_{T R P C 5}}$	0.002 ms^–1
	$k_{R_{T R P C 5}, 0}$	0.002 ms^–1	$g_{T R P C 5}$	8.4 nS (1.68 nS in OVX + E2)
	$K_{N K B}$	32 μM	$n 2$	2
	$R_{T R P C 5, T}$	1 μM	$E_{T R P C 5}$	–15 mV
$I_{G I R K}$	$V_{G I R K}$	–70 mV	$k_{G I R K, 1}$	20 mV		Tian et al., 2022
	$α$	0.8	$α_{τ}$	0.0061
	$k_{G I R K, 2}$	100 mV	$β_{τ}$	0.0818
	$g_{G I R K}$	0.4 nS	$E_{K}$	–81 mV
	$k_{R_{G I R K}, 0}$	0 ms^–1	$k_{R_{G I R K}}$	10^–3 ms^–1
	$R_{G I R K, T}$	1 μM	$K_{S}$	1 μM
	$k_{- R_{G I R K}}$	3.3⋅10^–6 ms^–1	$n 3$	2
$I_{l e a k}$	$g_{l e a k, 1}$	3.5 nS in OVX 3.65 nS in OVX + E2	$g_{l e a k, 2}$	4 nS		Fitted
Intracellular calcium
	$γ$	1.96 ⋅10^–5μM nA^–1 ms^–1	$d_{c a}$	0.008 ms^–1	Tsaneva-Atanasova et al., 2007
	$r$	0.9

Parameters g∙ denote the maximum conductance associated with each current.