Table 4.

Associations between plasma PUFA levels and mental disorders stratified by age and sex.

Plasma PUFAs	Mental Disorders	Age a		P for Interaction b	Sex		P for Interaction
Total PUFAs	Depressive disorder	<60	0.75 (0.63, 0.88)	0.269	Male	0.81 (0.67, 0.97)	0.352
		≥60	0.85 (0.72, 1.02)		Female	0.82 (0.70, 0.97)
	Anxiety disorder	<60	0.88 (0.74, 1.05)	0.348	Male	0.75 (0.61, 0.92)	0.038
		≥60	0.78 (0.65, 0.92)		Female	0.91 (0.78, 1.08)
Omega-3 PUFAs	Depressive disorder	<60	0.80 (0.68, 0.94)	0.040	Male	0.90 (0.75, 1.09)	0.436
		≥60	0.97 (0.80, 1.18)		Female	0.83 (0.71, 0.98)
	Anxiety disorder	<60	0.90 (0.76, 1.06)	0.984	Male	0.72 (0.59, 0.87)	0.072
		≥60	0.80 (0.67, 0.96)		Female	0.93 (0.79, 1.08)
DHA	Depressive disorder	<60	0.73 (0.62, 0.87)	0.031	Male	0.74 (0.60, 0.92)	0.667
		≥60	0.90 (0.75, 1.09)		Female	0.82 (0.69, 0.96)
	Anxiety disorder	<60	0.80 (0.67, 0.96)	0.556	Male	0.70 (0.56, 0.87)	0.235
		≥60	0.83 (0.69, 0.99)		Female	0.86 (0.73, 1.01)
Omega-6 PUFAs	Depressive disorder	<60	0.76 (0.64, 0.89)	0.615	Male	0.73 (0.60, 0.88)	0.186
		≥60	0.82 (0.69, 0.98)		Female	0.86 (0.73, 1.01)
	Anxiety disorder	<60	0.88 (0.74, 1.05)	0.496	Male	0.75 (0.61, 0.93)	0.069
		≥60	0.81 (0.68, 0.96)		Female	0.93 (0.79, 1.09)
LA	Depressive disorder	<60	0.74 (0.63, 0.87)	0.566	Male	0.68 (0.56, 0.83)	0.103
		≥60	0.81 (0.68, 0.97)		Female	0.84 (0.72, 0.98)
	Anxiety disorder	<60	0.84 (0.70, 1.00)	0.763	Male	0.76 (0.62, 0.93)	0.136
		≥60	0.85 (0.71, 1.01)		Female	0.90 (0.77, 1.06)

Abbreviation: DHA, docosahexaenoic acid; LA, linoleic acid. ^a Effect values are presented as hazard ratios with corresponding 95% CIs. ^b P for interaction was assessed based on a multiplicative scale by the addition of a product term to the model for testing the statistical significance of heterogeneity.