Table 5.
Associations between plasma PUFA levels and mental disorders stratified by the INFLA score and MetS.
| Plasma PUFAs |
Mental Disorders |
INFLA Score a |
P for Interaction b |
MetS |
P for Interaction |
||
|---|---|---|---|---|---|---|---|
| Total PUFAs |
Depressive disorder |
Low | 0.82 (0.69, 0.97) | 0.670 | Yes | 0.71 (0.59, 0.85) | 0.123 |
| High | 0.79 (0.67, 0.93) | No | 0.88 (0.75, 1.04) | ||||
| Anxiety disorder |
Low | 0.87 (0.73, 1.04) | 0.757 | Yes | 0.74 (0.61, 0.89) | 0.073 | |
| High | 0.79 (0.67, 0.94) | No | 0.91 (0.77, 1.06) | ||||
| Omega-3 PUFAs |
Depressive disorder |
Low | 0.91 (0.77, 1.09) | 0.371 | Yes | 0.77 (0.64, 0.93) | 0.107 |
| High | 0.83 (0.70, 0.98) | No | 0.92 (0.78, 1.07) | ||||
| Anxiety disorder |
Low | 0.79 (0.66, 0.93) | 0.256 | Yes | 0.76 (0.62, 0.93) | 0.319 | |
| High | 0.89 (0.75, 1.05) | No | 0.88 (0.75, 1.02) | ||||
| DHA | Depressive disorder |
Low | 0.83 (0.70, 0.98) | 0.331 | Yes | 0.71 (0.58, 0.87) | 0.090 |
| High | 0.78 (0.66, 0.94) | No | 0.89 (0.76, 1.05) | ||||
| Anxiety disorder |
Low | 0.70 (0.59, 0.84) | 0.074 | Yes | 0.69 (0.56, 0.85) | 0.170 | |
| High | 0.94 (0.79, 1.12) | No | 0.88 (0.75, 1.03) | ||||
| Omega-6 PUFAs |
Depressive disorder |
Low | 0.77 (0.65, 0.91) | 0.424 | Yes | 0.74 (0.62, 0.89) | 0.227 |
| High | 0.81 (0.69, 0.96) | No | 0.84 (0.71, 0.98) | ||||
| Anxiety disorder |
Low | 0.89 (0.74, 1.06) | 0.644 | Yes | 0.78 (0.65, 0.95) | 0.127 | |
| High | 0.80 (0.67, 0.95) | No | 0.89 (0.76, 1.05) | ||||
| LA | Depressive disorder |
Low | 0.74 (0.62, 0.87) | 0.256 | Yes | 0.75 (0.62, 0.89) | 0.464 |
| High | 0.81 (0.69, 0.96) | No | 0.80 (0.68, 0.94) | ||||
| Anxiety disorder |
Low | 0.87 (0.73, 1.04) | 0.942 | Yes | 0.84 (0.69, 1.01) | 0.473 | |
| High | 0.82 (0.69, 0.97) | No | 0.85 (0.72, 1.00) | ||||
Abbreviation: MetS, metabolic syndrome; DHA, docosahexaenoic acid; LA, linoleic acid. a Effect values are presented as hazard ratios with corresponding 95% CIs. b P for interaction was assessed based on a multiplicative scale by the addition of a product term to the model for testing the statistical significance of heterogeneity.