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Schematic diagram of formation and intracellular antioxidation of MPEG-2000-DSPE-edaravone (MDE). (A) Schematic structure of edaravone and methyl-PEG2000-DSPE self-assembly into micelles. (B) Edaravone and MDE targeting the focal-cell-attenuated over-generation of intracellular ROS. (C) Chemical structure of edaravone. (D) Chemical structure of methyl-PEG2000-DSPE.
