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. 2024 Dec 6;14(23):1962. doi: 10.3390/nano14231962

Figure 4.

Figure 4

Neuroprotective effects of MPEG-2000-DSPE-edaravone (MDE) on Parkinson’s disease cell model. A cell model of Parkinson’s disease was established in PC12 cells through exposure to rotenone (1 μM), and the reversible effects of MDE and edaravone were investigated. PC12 cells were divided into four groups: blank group (no treatment), rotenone group (1 μM rotenone), rotenone + MDE group (1 μM rotenone and 12.5 μg/mL MDE), and rotenone + EDR group (1 μM rotenone and edaravone solution). (A) Cell cycle determined via flow cytometry. (B) Cell apoptosis determined via flow cytometry. (C) Cell migration determined via wound healing assay. Each experiment was repeated at least six times. Scale bars are 200 μm.