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. 2024 Nov 24;16(23):3265. doi: 10.3390/polym16233265

Figure 8.

Figure 8

(A) HEK293 cells and (B) SH-SY5Y cells treated with BLOCK-iT™ fluorescent oligo (0.5 and 1.0 µg) conjugated to PLL-SLNPs at 1:1 and 2:1 (w/w) ratios. Intracellular fluorescence was measured after 24 h. (A) Control 1 = HEK293 cells only, and control 2 = naked/uncomplexed BLOCK-iT™ fluorescent oligo. Controls were compared to the nanocomplexes (*** p < 0.001) and further compared with the two treatment groups as indicated by the dotted line (** p < 0.005). (B) Control 1 = SH-SY5Y cells only, and control 2 = naked BLOCK-iT™ fluorescent oligo. Controls were compared to the nanocomplexes and further compared with the two treatment groups as indicated by the dotted line (*** p < 0.001). Statistically significant differences in the therapeutics were noted in both (A,B).