Figure 39.

(Left panel) A native structure of a lattice protein in a simple cubic lattice having $N=36$ amino acids (red circles). The structure is chosen to be maximally compact, where the numbers indicate the index of the ${\mathrm{C}}_{\alpha }$ along the chain. This structure has $n_c=40$ non-local contacts (or bridges) [363]. The sites (6, 27, 30) (connected by thin dashed lines) represent a sort of ‘hydrophobic core’ of the protein (see text below). (Right panel) The red sites (6,27,30) are denoted as hot sites, and the yellow ones (3,5,11,14,16,28) as warm sites [364]. Hot and warm sites happen to be first neighbors in the native structure either along the chain or as non-local contacts (see text below).