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. Author manuscript; available in PMC: 2024 Dec 14.
Published in final edited form as: Cell. 2024 Oct 8;187(25):7196–7213.e26. doi: 10.1016/j.cell.2024.09.026

Figure 4. VIR-7229 epitope encompasses sarbecovirus diversity.

Figure 4.

(A) Collapsed sarbecovirus phylogeny (left) with multiple sequence alignment of select sarbecoviruses (right) illustrating variation at VIR-7229 epitope positions. RBD numbering is relative to SARS-CoV-2. Dots indicate the SARS-CoV-2 Wuhan-Hu-1 identity. Heatmap at top of alignment illustrates extent of variation (white) or conservation (orange) across the entire sarbecovirus alignment, matched to the structural mapping in panel B. See Data S1 for full phylogeny and alignment.

(B) Sarbecovirus conservation of the VIR-7229 epitope mapped to SARS-CoV-2 Wuhan-Hu-1 RBD structure (PDB 6M0J). ACE2 binding footprint is illustrated as a black outline.