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. 2024 Aug 26;30(12):3646–3657. doi: 10.1038/s41591-024-03209-x

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© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — No significant differences were observed between participants with open vs. closed eyes within the same groups (two-sided permutation test, without multiple comparisons, and with 5000 algorithm iterations). We included 124 healthy controls with closed eyes and 86 with open eyes, 269 Alzheimer’s disease participants with closed eyes and 164 with open eyes, and 88 behavioral variant frontotemporal dementia with closed eyes and 69 with open eyes. For HC eyes open vs AD eyes open p < 1e-15, for HC eyes closed vs AD eyes closed p < 1e-15, for AD eyes open vs bvFTD eyes open p = 0.026, for AD eyes closed vs bvFTD eyes closed p = 0.004. * p < 0.05, ** p < 0.01, *** p < 0.001. HC = healthy controls, AD = Alzheimer’s disease, bvFTD = behavioral variant frontotemporal dementia, EC = eyes closed, EO = eyes open.