Extended Data Fig. 1. Measures of adiposity are highly correlated with liver triglycerides and inflammation/fibrosis, with VAT, WFM, and BMI being independent predictors of liver outcomes.

In (a), the phenotypic correlation between different measures of adiposity, liver triglyceride content measured by proton density fat fraction (PDFF), and inflammation/fibrosis measured by liver iron corrected T1 (cT1); pairwise Spearman’s correlation coefficients have been shown on the heatmap. All correlations had a Benjamini–Hochberg False Discovery Rate (FDR) <0.05. (b) penalized Ridge regression analysis of different adiposity indices in predicting PDFF and liver iron corrected T1. Each dot represents standardized coefficients, and dashed line represents the lack of contribution of each trait to the liver outcomes. Both target variables were rank-based inverse normal transformed before the regression analysis. VAT: visceral adipose tissue, WFM: whole-body fat mass, BMI: body mass index, IWB: impedance of whole body, WHR: waist-to-hip ratio.