Extended Data Fig. 2. Previously unknown genetic loci were associated with liver disease and metabolic traits.

Heatmap of the Z-score of associations for the effect (risk) allele between previously unknown genetic loci and liver or metabolic-related traits (columns) in n=397,780 UKBB participants after excluding individuals with available PDFF or liver iron corrected T1 (n=36,748). The association analyses were performed by linear or logistic regression analysis using REGENIE and adjusted for adiposity index, age, sex, age×sex, age² and age²×sex, first 10 genomic principal components and array batch. Upper and lower boxes correspond to liver iron corrected T1 and PDFF genetic loci, respectively. Full summary statistics have been reported in Supplementary Table 11. P values were two-sided and not corrected for multiple hypothesis testing. VAT: Visceral adipose tissue; WFM: Whole-body fat mass (kg/m2); cT1: liver iron corrected T1; PDFF: proton density fat fraction; CLD: chronic liver disease.