Table 1.
Sensitivity to venetoclax in HMCLs.
| Human MM cell lines | Sensitivity to venetoclax | IGH tx | TP53 status | Ratio Bcl2/Mcl1 | Ratio Bcl2/Bcl‐xl | Ratio Bcl2+Bim+Bax/Bcl‐XL |
|---|---|---|---|---|---|---|
| SK‐MM‐2 | Yes | t(11;14) | DH | 6.39 | 56.98 | 412.12 |
| KMS12‐PE | Yes | t(11;14) | DH | 0.67 | 18.86 | 122.4 |
| KMS12‐BM | Yes | t(11;14) | DH | 0.33 | 5.21 | 32.21 |
| KMS28‐BM | Yes | t(4;14) | DH | 0.6 | 4.36 | 26.68 |
| JJN‐3 | Yes | t(14;16) | No expression | 0.26 | 3.5 | 23.33 |
| U266 | No | t(11;14) | DH | 0.14 | 0.47 | 5.57 |
| H929 | No | t(4,14) | WT | 0.03 | 0.31 | 2.24 |
| MM.1S | No | t(14;16) | WT | 0.12 | 0.21 | 3.22 |
| MOLP‐8 | No | t(11;14) | WT | 0 | 0 | 18.45 |
Abbreviations: DH, TP53 double hit; WT, TP53 wild type.
HMCLs sensitive to venetoclax.
HMCLs with low sensitivity to venetoclax.
HMCLs resistant to venetoclax.