Fig. 2.

Dexamethasone (DXM) significantly ameliorates the behavioral deficits exhibited by NM-PD mice. (A) Timeline of AAV Administration, motor testing, and procedures in different experimental groups of C57BL/6J mice over 5 weeks. (B) Motor coordination was analyzed by measuring the latency to fall in accelerating rotarod test (Rotarod test) at 3- and 5- weeks post-injection. Muscular rigidity was evaluated by measuring the time required for the mice to withdraw their forepaws from a bar (Catalepsy test) at 3- and 5- weeks post-injection. (n = 5–9 per group). Data are presented as mean ± standard error of the mean (SEM). One-way ANOVA followed by Tukey post hoc test was used. *p ≤ 0.05, **p ≤ 0.01, better ***p ≤ 0.001****p ≤ 0.0001