Fig. 3.

Dexamethasone prevents the loss of dopaminergic neurons in the SNpc of NM-PD mice. (A) Representative photomicrographs showing TH + dopaminergic neurons in the midbrain of C57BL/6J mice at 3 and 5 weeks following AAV9-null and AAV9-hTyr injections and treated with Dexamethasone (DXM) or vehicle. (B) Quantification of TH + neurons in the midbrain of C57BL/6J mice at 3 and 5 weeks following AAV9-null and AAV9-hTyr injections and treated with DXM or vehicle. (C) Representative photomicrographs showing TH-immunoreactivity in the striatum of C57BL/6J mice at 3 and 5 weeks following AAV9-null and AAV9-hTyr injections and treated with DXM or vehicle. (D) TH + fibers measured by optical densitometry in striatum of C57BL/6J mice at 3 and 5 weeks following AAV9-null and AAV9-hTyr and treated with DXM or vehicle (n = 5 per group). Magnification bar (A) 1 mm. Data are presented as mean ± standard error of the mean (SEM). One-way ANOVA followed by Tukey post hoc test was used.***p ≤ 0.001****p ≤ 0.0001