Fig. 5.

Dexamethasone inhibits AAV9-hTyr-induced activated phagocytic microglia in the SNpc of C57BL/6J mice at 3 weeks post-injection. (A) Representative photomicrographs showing CD68 + cells in the midbrain of C57BL/6J mice 3 and 5 weeks after the AAV9-null and AAV9-hTyr injection and treated with Dexamethasone (DXM) or vehicle. (B) Quantification of CD68 + cells in the midbrain of C57BL/6J mice 3 and 5 weeks after the AAV9-null and AAV9-hTyr injection and treated with DXM or vehicle. (C) Representative images of double labelling of Iba1 (red) and CD68 (green) of C57BL/6J mice 3 weeks after AAV9-null and AAV9-hTyr injection and treated with DXM or vehicle. Magnification bar (A) 1 mm in sets with low magnification and 200 μm in sets with high magnification. Data are presented as mean ± standard error of the mean (SEM). One-way ANOVA followed by Tukey post hoc test was used. **p ≤ 0.01 ***p ≤ 0.001****p ≤ 0.0001