Fig. 6.

Dexamethasone inhibits AAV9-hTyr-induced brain extravasation of lymphocytes in the SNpc. Representative images of CD3 immunostaining in the midbrain of C57BL/6J mice 3 (A) and 5 (B) weeks after the AAV9-null and AAV9-hTyr injection and treated with Dexamethasone (DXM) or vehicle. (C) Quantification of CD3 + cells in the midbrain of C57BL/6J mice 3 and 5 weeks after the AAV9-null and AAV9-hTyr injection and treated with DXM or vehicle. (D) Quantification of CD3+, CD4 + and CD8 + cells in peripheral blood of C57BL/6J mice after treatment with DXM (1 mg/kg) or vehicle during 15 days (n = 4 per group). Data are presented as mean ± standard error of the mean (SEM). One-way ANOVA followed by Tukey post hoc test was used.*p ≤ 0.05, **p ≤ 0.01. Magnification bar 1 mm and 200 μm in sets with high magnification