Figure 1.

Schematic representation of BICEP. The prior odds of causality (PriorOC) are generated from genomic annotation information, independent of the pedigree data. The BF is generated based on the sequencing data, the pedigree structure, and the phenotypes. These are then considered on the base 10 logarithmic scale (logPriorOC and logBF) and summed to give the posterior odds of causality on the base 10 logarithmic scale (logPostOC). The dashed lines in the BF and logBF plots indicate the maximum achievable value for the pedigree (i.e. perfect cosegregation with the phenotype with complete penetrance and no phenocopies).