Figure 2.

Promoter methylation analysis and diagnostic performance of pituitary tumor-transforming gene (PTTG) genes in lung adenocarcinoma (LUAD) and control cell lines. A. Box plots of beta values obtained from bisulfite sequencing indicate the promoter methylation levels of PTTG1, PTTG2, and PTTG3P genes in LUAD (red) and control (blue) cell lines. B. Receiver operating characteristic (ROC) curves evaluating the diagnostic accuracy of promoter methylation levels for PTTG1, PTTG2, and PTTG3P. The areas under the curve (AUC) values are 0.81 for PTTG1, 0.84 for PTTG2, and 0.88 for PTTG3P, demonstrating good discriminative power between LUAD and normal individuals, with PTTG3P showing the highest diagnostic potential. *P-value < 0.05.