Table 1.
Location of histologic lesions and immunoreactivity (IHC) for influenza A virus nucleoprotein in cats naturally infected with influenza A(H5N1) virus from Texas and New Mexico.
| Location | Presence or absence of lesions/IHC results | No. of cats with lesions | No. of cats IHC+ | |||
|---|---|---|---|---|---|---|
| Cat 1 (case 1) | Cat 2 (case 1) | Cat 3 (case 2) | Cat 4 (case 2) | |||
| Brainstem | +/+ | +/+ | +/+ | NA | 3/3 | 3/3 |
| Cerebellum | –/– | –/– | +/– | NA | 1/3 | 0/3 |
| Cerebrum | +/+ | +/+ | +/+ | +/+ | 4/4 | 4/4 |
| Spinal cord | NA | NA | +/– | NA | 1/1 | 0/1 |
| Peripheral nerves | NA | NA | –/– | NA | 0/1 | 0/1 |
| Eye (retina, choroid) | –/– | +/+ | +/+ | –/– | 2/4 | 2/4 |
| Ocular conjunctiva | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Eyelid conjunctiva | NA | NA | –/– | +/– | 1/2 | 0/2 |
| Lacrimal gland | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Nasal turbinates | NA | NA | –/– | +/– | 1/2 | 0/2 |
| Cribriform plate | NA | NA | –/– | +/– | 1/2 | 0/2 |
| Larynx | NA | NA | –/– | NA | 0/1 | 0/1 |
| Trachea | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Lung | +/+ | +/+ | +/– | +/– | 4/4 | 2/4 |
| Tonsil | NA | NA | +/– | NA | 1/1 | 0/1 |
| Lymph node | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Spleen | –/– | –/– | –/– | –/– | 0/4 | 0/4 |
| Submandibular salivary gland | NA | NA | +/+ | +/– | 2/2 | 1/2 |
| Minor salivary glands—pharynx | NA | NA | NA | +/– | 1/1 | 0/1 |
| Minor salivary glands—tongue | NA | NA | +/+ | NA | 1/1 | 1/1 |
| Parotid gland | NA | NA | –/– | +/– | 1/2 | 0/2 |
| Sublingual salivary glands | NA | NA | –/– | NA | 0/1 | 0/1 |
| Tongue | NA | NA | –/– | NA | 0/1 | 0/1 |
| Esophagus | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Stomach | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Large intestine | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Small intestine | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Heart | +/+ | +/+ | +/– | –/– | 3/4 | 2/4 |
| Skeletal muscle | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Liver | –/– | –/– | +/– | –/– | 1/4 | 0/4 |
| Kidney | –/– | –/– | –/– | –/– | 0/4 | 0/4 |
| Urinary bladder | NA | NA | –/– | NA | 0/1 | 0/1 |
| Adrenal gland | NA | NA | +/– | –/– | 1/2 | 0/2 |
| Parathyroid gland | NA | NA | –/– | NA | 0/1 | 0/1 |
| Thyroid gland | NA | NA | +/– | –/– | 1/2 | 0/2 |
| Pancreas | NA | NA | –/– | –/– | 0/2 | 0/2 |
| Ovary | NA | NA | –/– | NA | 0/1 | 0/1 |
| Uterus | NA | NA | –/– | NA | 0/1 | 0/1 |
| Bone marrow | NA | NA | –/– | NA | 0/1 | 0/1 |
+
= lesion present or positive IHC; – = lesion absent or negative IHC; NA = not available.