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. 1977 Jan 15;162(1):213–216. doi: 10.1042/bj1620213

Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action.

F De Matteis, A H Gibbs
PMCID: PMC1164588  PMID: 849279

Abstract

Cobalt inhibits liver haem synthesis in vivo by acting at least two different sites in the biosynthetic pathway: (1) synthesis of 5-aminolaevulinate and (2) conversion of 5-amino-laevulinate into haem. The first effect is largely, if not entirely, due to inhibition of the activity of 5-aminolaevulinate synthase, rather than to inhibition of the formation of the enzyme. The second effect results from diversion of 5-aminolaevulinate into an unidentified liver pool with solubility properties similar to those of cobalt protoporphyrin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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