FIGURE 2.

Number of participants with altered phenotypes in pharmacogenes associated with sedatives and analgesics. An altered phenotype was defined as any phenotype associated with genetic variants (i.e., not wild type) according to the OneOme genotype to phenotype algorithm. The normal/typical phenotype for CYP3A5 was defined as poor metabolizers carrying CYP3A5*3/*3 due to the high prevalence of this genetic variant in our study population of mostly Caucasians. A participant may be counted in more than one of the phenotypes.