TABLE 2.

RASS and medications during the first 24 h on mechanical ventilation ^a .

Study period	Medication profile		Summary statistic
First 24 h	Number of RASS measurements per participant, median [IQR]		12 [12, 12]
	Time on sedatives/analgesics with a potentially relevant pharmacogene, hours median [IQR]		24 [22, 24]
	Number of altered phenotypes per patient, median [IQR]		2 [1, 3]
	Fentanyl weight normalized cumulative 24‐h dose, median [IQR] (mcg/h/kg)		6.81 [3.8, 12.3]
	Propofol weight normalized cumulative 24‐h dose, median [IQR] (mcg/min/kg)		260 [162, 405]
	Dexmedetomidine weight normalized cumulative 24‐h dose, median [IQR] (mcg/h/kg)		3 [1.15, 4.6]
	Midazolam weight normalized cumulative 24‐h dose, median [IQR] (mg/kg)		0.198 [0.03, 0.34]
	Fentanyl, n (%)	Did not receive medication	11 (14.1)
		Low weight normalized cumulative dose	33 (42.3)
		High weight normalized cumulative dose	34 (43.6)
	Propofol, n (%)	Did not receive medication	11 (14.1)
		Low weight normalized cumulative dose	33 (42.3)
		High weight normalized cumulative dose	34 (43.6)
	Dexmedetomidine, n (%)	Did not receive medication	43 (55.1)
		Low weight normalized cumulative dose	17 (21.8)
		High weight normalized cumulative dose	18 (23.1)
	Midazolam, n (%)	Did not receive medication	60 (76.9)
		Low weight normalized cumulative dose	9 (11.5)
		High weight normalized cumulative dose	9 (11.5)

Abbreviations: IQR, interquartile range; RASS, Richmond Agitation‐sedation scale.

^a Low cumulative dose is below the median cumulative dose and high is above the median cumulative dose in the first 24 h.