TABLE 4.
Association between the number of altered PGx phenotypes and percentage of time in target RASS in the first 24 and 48 h.
| Endpoint | Percentage of time in target RASS range | Number of participants achieving target (total n = 78) | aOR of number of altered phenotypes (95% CI) a | p‐value |
|---|---|---|---|---|
| 24 h | ≥60% | 15 | 0.61 (0.24–1.37) | 0.25 |
| ≥70% | 9 | 0.46 (0.08–1.50) | 0.27 | |
| 48 h | ≥60% | 23 | 0.96 (0.48–1.89) | 0.91 |
| ≥70% | 15 | 0.52 (0.19–1.24) | 0.17 |
Abbreviations: aOR, adjusted odds ratio; CI, confidence interval; RASS, Richmond Agitation‐Sedation Scale.
a
Adjusted for age, sex, ICU unit, creatinine clearance, baseline RASS measurement, and medication dose groups (high, low, and not received) based on the cumulative weight‐adjusted dose for fentanyl, propofol, midazolam, and dexmedetomidine.