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. 1977 Mar 15;162(3):493–499. doi: 10.1042/bj1620493

Nature of the stimulation of biogenesis of cholesterol in the liver by noradrenaline.

R George, T Ramasarma
PMCID: PMC1164632  PMID: 68775

Abstract

1. Administration of noradrenaline increased the incorporation of [1-14C]acetate into hepatic sterols and the activity of liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. 2. The stimulation was observed at short time-intervals with a maximum at 4h and was progressive with increasing concentrations of noradrenaline. 3. Protein synthesis de novo was a necessary factor for the effect. 4. The stimulatory effect was not mediated through the adrenergic receptors, but appears to involve a direct action of the hormone within the hepatocyte.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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