TABLE 2.
Characteristics and treatment outcomes of registered fresh cycles in assisted reproductive technology in Japan, 2022.
| Variables | IVF | Split‐ICSI | ICSI | Frozen oocyte | Other a | Total | |
|---|---|---|---|---|---|---|---|
| Ejaculated sperm | TESE | ||||||
| No. of registered cycles | 85 124 | 34 581 | 150 958 | 2277 | 2628 | 3650 | 279 218 |
| No. of egg retrievals (0 or more) | 83 586 | 34 293 | 148 923 | 2273 | 2608 | 3613 | 275 296 |
| No. of fresh ET cycles (1 or more) | 11 951 | 2907 | 16 088 | 304 | 0 | 260 | 31 510 |
| No. of freeze‐all cycles | 45 068 | 27 010 | 80 436 | 1368 | 2402 | 1963 | 158 247 |
| No. of cycles with pregnancy | 2942 | 752 | 3084 | 42 | 0 | 65 | 6885 |
| Pregnancy rate per ET | 24.6% | 25.9% | 19.2% | 13.8% | 25.0% | 21.9% | |
| Pregnancy rate per egg retrieval | 3.5% | 2.2% | 2.1% | 1.9% | 1.8% | 2.5% | |
| Pregnancy rate per egg retrieval excluding freeze‐all cycles | 4.5% | 3.6% | 2.7% | 2.6% | 2.0% | 3.3% | |
| SET cycles | 10 321 | 2529 | 12 721 | 186 | 220 | 25 977 | |
| Pregnancy following SET cycles | 2586 | 686 | 2515 | 32 | 61 | 5880 | |
| Rate of SET cycles | 86.4% | 87.0% | 79.1% | 61.2% | 84.6% | 82.4% | |
| Pregnancy rate following SET cycles | 25.1% | 27.1% | 19.8% | 17.2% | 27.7% | 22.6% | |
| Miscarriages | 709 | 158 | 785 | 14 | 12 | 1678 | |
| Miscarriage rate per pregnancy | 24.1% | 21.0% | 25.5% | 33.3% | 18.5% | 24.4% | |
| Singleton pregnancies b | 2801 | 720 | 2931 | 41 | 63 | 6556 | |
| Multiple pregnancies b | 74 | 20 | 90 | 0 | 2 | 186 | |
| Twin pregnancies | 73 | 20 | 88 | 0 | 0 | 183 | |
| Triplet pregnancies | 1 | 0 | 2 | 0 | 0 | 3 | |
| Quadruplet pregnancies | 0 | 0 | 0 | 0 | 0 | 0 | |
| Multiple pregnancy rate | 2.6% | 2.7% | 3.0% | 0.0% | 3.1% | 2.8% | |
| Live births | 2082 | 553 | 2172 | 26 | 50 | 4883 | |
| Live birth rate per ET | 17.4% | 19.0% | 13.5% | 8.6% | 19.2% | 15.5% | |
| Total no. of neonates | 2133 | 568 | 2228 | 26 | 50 | 5005 | |
| Singleton live births | 2031 | 538 | 2113 | 26 | 50 | 4758 | |
| Twin live births | 51 | 15 | 56 | 0 | 0 | 122 | |
| Triplet live births | 0 | 0 | 1 | 0 | 0 | 1 | |
| Quadruplet live births | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ectopic pregnancies | 39 | 4 | 39 | 1 | 1 | 84 | |
| Heterotopic pregnancies | 1 | 0 | 0 | 0 | 0 | 1 | |
| Artificial abortions | 11 | 4 | 19 | 1 | 1 | 36 | |
| Still births | 12 | 1 | 9 | 0 | 0 | 22 | |
| Fetal reductions | 0 | 0 | 1 | 0 | 0 | 1 | |
| Cycles with unknown pregnancy outcomes | 57 | 27 | 47 | 0 | 1 | 132 | |
Abbreviations: ET, embryo transfer; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilization; SET, single embryo transfer; TESE, testicular sperm extraction; ZIFT, zygote intrafallopian transfer.
a
Others include ZIFT.
b
Singleton, twin, triplet, and quadruplet pregnancies were defined on the basis of the number of gestational sacs in utero.